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Inhibition of telomerase using BIBR1532 enhances doxorubicin-induced apoptosis in pre-B acute lymphoblastic leukemia cells

5 Jan 2017

Abstract excerpt

OBJECTIVES: Interest into targeting telomerase in cancer has increased by the recent disclosure that elevated telomerase activity is associated with disease recurrence and poor outcome in cancers. In addition, cellular acquisition of unlimited replicative potential, which is closely related to the maintenance of telomeres mostly via the reactivation of telomerase, has been shown to confer loss of sensitivity to a...

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Share to Cell death mechanisms and regulation
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Share to Telomeres, Telomerase, and Senescence

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PMID: 28054503
DOI: 10.1080/10245332.2016.1275426

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