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Article

Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration.

The Journal of biological chemistry - 12 Dec 2003

Gomez Dennis, Aouali Nassera, Londoño-Vallejo Arturo, Lacroix Laurent, Mégnin-Chanet Frédérique, Lemarteleur Thibault, Douarre Céline, Shin-ya Kazuo, Mailliet Patrick, Trentesaux Chantal, Morjani Hamid, Mergny Jean-Louis, Riou Jean-François

Abstract excerpt

Ligands that stabilize the telomeric G-rich single-stranded DNA overhang into G-quadruplex can be considered as potential antitumor agents that block telomere replication. Ligand 12459, a potent G-quadruplex ligand that belongs to the triazine series, has been previously shown to induce both telo...

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Identifiers

PMID: 14525974
DOI: 10.1074/jbc.M308440200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14525974-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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