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Article

Consequences of Telomerase Inhibition by BIBR1532 on Proliferation and Chemosensitivity of Chondrosarcoma Cell Lines

1 Jan 2008

Abstract excerpt

PURPOSE: Human chondrosarcomas are generally resistant to conventional treatments like chemotherapy and radiotherapy. We investigated the effects of BIBR1532, an inhibitor of telomerase on chondrosarcoma cells in vitro. METHODS: Telomerase activity, telomere lengths, growth kinetics and chemosensitivity were analyzed in chondrosarcoma cell lines treated with BIBR1532. RESULTS: BIBR1532 treatment resulted in...

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Share to DNA and Nucleic Acid Chemistry
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PMID: 18584350
DOI: 10.1080/07357900802072905

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