Article
A Salmonella virulence protein that inhibits cellular trafficking.
The EMBO journal - 15 Jul 1999
Uchiya K, Barbieri M A, Funato K, Shah A H, Stahl P D, Groisman E A
Abstract excerpt
Salmonella enterica requires a type III secretion system, designated Spi/Ssa, to survive and proliferate within macrophages. The Spi/Ssa system is encoded within the SPI-2 pathogenicity island and appears to function intracellularly. Here, we establish that the SPI-2-encoded SpiC protein is exported by the Spi/Ssa type III secretion system into the host cell cytosol where it interferes with intracellular...
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