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Article

WT1 Activates a Glomerular-Specific Enhancer Identified from the Human Nephrin Gene

23 Oct 2004

Abstract excerpt

The glomerular filtration barrier separates the blood from the urinary space. Nephrin is a transmembrane protein that belongs to the immunoglobulin superfamily and is localized to the slit diaphragms that are a critical component of this filtration barrier. Mutations in the nephrin gene (NPHS1) lead to congenital Finnish nephropathy, whereas alterations in the level of nephrin expression have been identified in a...

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PMID: 15504938
DOI: 10.1097/01.asn.0000143474.91362.c4

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