Article
Antipneumococcal activities of two novel macrolides, GW 773546 and GW 708408, compared with those of erythromycin, azithromycin, clarithromycin, clindamycin, and telithromycin.
Antimicrobial agents and chemotherapy - 1 Nov 2004
Matic Vlatka, Kosowska Klaudia, Bozdogan Bulent, Kelly Linda M, Smith Kathy, Ednie Lois M, Lin Gengrong, Credito Kim L, Clark Catherine L, McGhee Pamela, Pankuch Glenn A, Jacobs Michael R, Appelbaum Peter C
Abstract excerpt
The MICs of GW 773546, GW 708408, and telithromycin for 164 macrolide-susceptible and 161 macrolide-resistant pneumococci were low. The MICs of GW 773546, GW 708408, and telithromycin for macrolide-resistant strains were similar, irrespective of the resistance genotypes of the strains. Clindamycin was active against all macrolide-resistant strains except those with erm(B) and one strain with a 23S rRNA mutation....
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