Article
Time-kill study of the activity of telithromycin against macrolide-resistant Streptococcus pneumoniae Isolates with 23S rRNA mutations and changes in ribosomal proteins L4 and L22.
Antimicrobial agents and chemotherapy - 1 Jul 2005
Reinert Ralf René, Al-Lahham Adnan
Abstract excerpt
By use of a time-kill methodology, the antipneumococcal activity of telithromycin was determined against macrolide-resistant S. pneumoniae isolates having mutations in the 23S rRNA gene and changes in the ribosomal proteins L4 and L22. Telithromycin had MICs ranging between 0.03 and 0.25 microg/ml and was bactericidal against four of seven strains after 24 h at two times the MIC.
Topics
- Anti-Bacterial Agents
- Drug Resistance, Bacterial
- Humans
- Ketolides
- Macrolides
- Microbial Sensitivity Tests
- Mutation
- RNA, Ribosomal, 23S
- Ribosomal Proteins
- Streptococcus pneumoniae
- Time Factors