Article
Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America.
Antimicrobial agents and chemotherapy - 1 Dec 2000
Tait-Kamradt A, Davies T, Appelbaum P C, Depardieu F, Courvalin P, Petitpas J, Wondrack L, Walker A, Jacobs M R, Sutcliffe J
Abstract excerpt
Resistance to macrolides in pneumococci is generally mediated by methylation of 23S rRNA via erm(B) methylase which can confer a macrolide (M)-, lincosamide (L)-, and streptogramin B (S(B))-resistant (MLS(B)) phenotype or by drug efflux via mef(A) which confers resistance to 14- and 15-membered macrolides only. We studied 20 strains with unusual ML or MS(B) phenotypes which did not harbor erm(B) or mef(A). The...
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