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Article

A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans.

Current genetics - 1 Nov 2004

Wang Ping, Cox Gary M, Heitman Joseph

Abstract excerpt

The polysaccharide capsule is one of the established virulence factors in Cryptococcus neoformans that provides a barrier against the host-mediated immune response. Mutation of the gene encoding the Saccharomyces cerevisiae Sch9 protein kinase homologue resulted in cells with enlarged capsules in C. neoformans. Capsule production was abrogated in sch9 pka1 double mutants, indicating that protein kinase A (PKA)...

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Identifiers

PMID: 15503029
DOI: 10.1007/s00294-004-0529-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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