The <b> <i>In vitro</i> </b> and <b> <i>In vivo</i> </b> Effects of Re-Expressing Methylated <b> <i>von Hippel-Lindau</i> </b> Tumor Suppressor Gene in Clear Cell Renal Carcinoma with 5-Aza-2′-deoxycytidine

Abstract excerpt

PURPOSE: Clear cell renal carcinoma (ccRCC) is strongly associated with loss of the von Hippel-Lindau (VHL) tumor suppressor gene. The VHL gene is functionally lost through hypermethylation in up to 19% of sporadic ccRCC cases. We theorized that re-expressing VHL silenced by methylation in ccRCC cells, using a hypo-methylating agent, may be an approach to treatment in patients with this type of cancer. We test...

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