Article
Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 2005
Hauet Thierry, Yao Zhi-Xing, Bose Himangshu S, Wall Christopher T, Han Zeqiu, Li Wenping, Hales Dale B, Miller Walter L, Culty Martine, Papadopoulos Vassilios
Abstract excerpt
Hormone-induced steroid biosynthesis begins with the transfer of cholesterol from intracellular stores into mitochondria. Steroidogenic acute regulatory protein (StAR) and peripheral-type benzodiazepine receptor (PBR) have been implicated in this rate-determining step of steroidogenesis. MA-10 mouse Leydig tumor cells were treated with and without oligodeoxynucleotides (ODNs) antisense to PBR and StAR followed by...
Topics
- Animals
- Blotting, Western
- Cell Line, Tumor
- Cell Survival
- Cholesterol
- Cyclic AMP-Dependent Protein Kinases
- Dose-Response Relationship, Drug
- Gonadotropins
- Humans
- Hydroxycholesterols