Article
Role of the steroidogenic acute regulatory protein (StAR) in steroidogenesis.
Biochemical pharmacology - 9 Feb 1996
Stocco D M, Clark B J
Abstract excerpt
The rate-limiting, hormone-regulated, enzymatic step in steroidogenesis is the conversion of cholesterol to pregnenolone by the cholesterol side-chain cleavage enzyme system (CSCC), which is located on the matrix side of the inner mitochondrial membrane. However, it has long been observed that hydrophilic cholesterol-like substrates capable of traversing the mitochondrial membranes are cleaved to pregnenolone by...
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