Article
Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis.
Steroids - 1 Jan 1997
Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown A S, Reversa J L, Bernassau J M, Drieu K
Abstract excerpt
Steroidogenesis begins with the metabolism of cholesterol to pregnenolone by the inner mitochondrial membrane cytochrome P450 side-chain cleavage (P450scc) enzyme. The rate of steroid formation, however, depends on the rate of cholesterol transport from intracellular stores to the inner mitochondrial membrane and loading of P450scc with cholesterol. In previous in vitro studies, we demonstrated that a key element...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.