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Article

Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein.

Molecular cell - 22 Oct 2004

Narayanan Usha, Achsel Tilmann, Lührmann Reinhard, Matera A Gregory

Abstract excerpt

Cytoplasmic assembly of Sm-class small nuclear ribonucleoproteins (snRNPs) is a central process in eukaryotic gene expression. A large macromolecular complex containing the survival of motor neurons (SMN) protein is required for proper snRNP assembly in vivo. Defects in SMN function lead to a human neuromuscular disorder, spinal muscular atrophy (SMA). SMN protein localizes to both nuclear and cytoplasmic...

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Source

Identifiers

PMID: 15494309
DOI: 10.1016/j.molcel.2004.09.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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