Article
Mutation induction by heavy-ion irradiation of gpt delta transgenic mice.
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) - 1 Jan 2001
Yatagai F, Nohmi T, Kusakabe M, Masumura K, Yoshiki A, Yamaguchi H, Kurobe T, Kuniya K, Hanaoka F, Yano Y
Abstract excerpt
Using the new transgenic mice produced by mating gpt delta with p53 knockout, mutation induction by heavy-ion irradiation and the effect of p53 background on such induction were studied. After the whole body irradiation with 10 Gy of 135 MeV/u carbon-ion beam, the genomic DNA was isolated from the different organs and the lambda DNA was rescued as a phage. Mutations in the transgene on the lambda DNA were...
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