Article
p16INK4a polymorphism: associations with tumour progression in patients with sporadic colorectal cancer.
International journal of oncology - 1 Nov 2004
McCloud Jonathan M, Sivakumar Rangasamy, Greenhough Alex, Elder Jackie, Jones Peter W, Deakin Mark, Elder James B, Fryer Anthony A, Hoban Paul R
Abstract excerpt
Deregulated tumour expression of p16INK4a has previously been described in association with clinical progression in sporadic colorectal cancer patients (CRC). Furthermore, p16INK4a promoter hypermethylation leading to gene silencing has been shown to occur in advanced colorectal tumours and has been associated with patient survival. p16INK4a is polymorphic, with variant alleles being associated with tumour...
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