Article
Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease.
The Journal of biological chemistry - 31 Dec 2004
Shiina Takahiko, Konno Akihiro, Oonuma Toshina, Kitamura Hiroshi, Imaoka Koichi, Takeda Naoki, Todokoro Kazuo, Morimatsu Masami
Abstract excerpt
MAIL (molecule-possessing ankyrin repeats induced by lipopolysaccharide) is a nuclear IkappaB protein that is also termed interleukin-1-inducible nuclear ankyrin repeat protein or inhibitor of nuclear factor kappaB (IkappaB) zeta. In this study, we generated Mail-/- mice to investigate the roles of MAIL in whole organisms. Mail-/- mice grew normally until 4-8 weeks after birth, when they began to develop lesions...
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