Article
Leukemia and lymphoma in ataxia telangiectasia.
Blood - 15 Jan 1996
Taylor A M, Metcalfe J A, Thick J, Mak Y F
Abstract excerpt
There is a large increase in lymphoid malignancy in A-T patients and a total absence of myeloid tumors. Penetrance of the tumor phenotype is about 10% to 15% by early adulthood. The increase in lymphoid malignancy includes both B- and T-cell tumors. However, young A-T patients do not show an increased susceptibility to cALL, and the UK data suggest that B-cell lymphoma occurs in older A-T children. T-cell tumors...
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