Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepcidin is decreased in TFR2 hemochromatosis.

Blood - 15 Feb 2005

Nemeth Elizabeta, Roetto Antonella, Garozzo Giovanni, Ganz Tomas, Camaschella Clara

Abstract excerpt

The hepatic peptide hepcidin is the key regulator of iron metabolism in mammals. Recent evidence indicates that certain forms of hereditary hemochromatosis are caused by hepcidin deficiency. Juvenile hemochromatosis is associated with hepcidin or hemojuvelin mutations, and these patients have low or absent urinary hepcidin. Patients with C282Y HFE hemochromatosis also have inappropriately low hepcidin levels for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged
Share to Antimicrobial Cationic Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Hemochromatosis

Share to Hepcidins

Share to Mutation

Share to Receptors, Transferrin

Source

Identifiers

PMID: 15486069
DOI: 10.1182/blood-2004-08-3042

Genes

TFR2
HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepcidin is decreased in TFR2 hemochromatosis.PMID 15486069Read ↗

Expression of hepcidin and other iron-related genes in type 3 hemochromatosis due to a novel mutation in transferrin receptor-2.Semantic proximity Read ↗

The Molecular Pathogenesis of Hereditary HemochromatosisSemantic proximity Read ↗

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis.Semantic proximity Read ↗

Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis.Semantic proximity Read ↗

New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis.Semantic proximity Read ↗

Identification of a novel mutation in the HAMP gene that causes non-detectable hepcidin molecules in a Japanese male patient with juvenile hemochromatosis.Semantic proximity Read ↗

TFR2-related haemochromatosis in the Netherlands: a cause of arthralgia in young adulthood.Semantic proximity Read ↗

Non-HFE haemochromatosis.Semantic proximity Read ↗

Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders.Semantic proximity Read ↗

Identification of new mutations of hepcidin and hemojuvelin in patients with HFE C282Y allele.Semantic proximity Read ↗

Duodenal expression of iron transport molecules in patients with hereditary hemochromatosis or iron deficiency.Semantic proximity Read ↗

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.