Article
Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders.
Journal of gastroenterology - 1 Nov 2010
Kaneko Yoshibumi, Miyajima Hiroaki, Piperno Alberto, Tomosugi Naohisa, Hayashi Hisao, Morotomi Natsuko, Tsuchida Ken-ichi, Ikeda Takaaki, Ishikawa Akihisa, Ota Yusuke, Wakusawa Shinya, Yoshioka Kentaro, Kono Satoshi, Pelucchi Sara, Hattori Ai, Tatsumi Yasuaki, Okada Toshihide, Yamagishi Masakazu
Abstract excerpt
BACKGROUND: Iron overload syndromes include a wide spectrum of genetic and acquired conditions. Recent studies suggest suppressed hepcidin synthesis in the liver to be the molecular basis of hemochromatosis. However, a liver with acquired iron overload synthesizes an adequate amount of hepcidin. Thus, hepcidin could function as a biochemical marker for differential diagnosis of iron overload syndromes. METHODS:...
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