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Article

The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly.

Molecular and cellular biology - 1 Nov 2004

Laurent Charles E, Delfino Frank J, Cheng Haiyun Y, Smithgall Thomas E

Abstract excerpt

The c-Fes protein-tyrosine kinase (Fes) has been implicated in the differentiation of vascular endothelial, myeloid hematopoietic, and neuronal cells, promoting substantial morphological changes in these cell types. The mechanism by which Fes promotes morphological aspects of cellular differentiation is unknown. Using COS-7 cells as a model system, we observed that Fes strongly colocalizes with microtubules in...

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Identifiers

PMID: 15485904
DOI: 10.1128/MCB.24.21.9351-9358.2004
PMCID: PMC522259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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