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Article

The contrasting oncogenic and tumor suppressor roles of FES.

Frontiers in bioscience (Scholar edition) - 1 Jan 2012

Greer Peter A, Kanda Shigeru, Smithgall Thomas E

Abstract excerpt

The FES gene was first discovered as a protein-tyrosine kinase-encoding retroviral oncogene. The ability of v-FES to transform cells in vitro and initiate cancer in vivo has been established by cell culture, engraftment and transgenic mouse studies. The corresponding cellular c-FES proto-oncogene encodes a cytoplasmic FES protein-tyrosine kinase with restrained catalytic activity relative to its retrovirally...

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Identifiers

PMID: 22202072
DOI: 10.2741/280

Genes

FES

Provenance

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