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Article

Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac.

The Journal of biological chemistry - 11 Feb 2005

Kawakatsu Tomomi, Ogita Hisakazu, Fukuhara Tatsuro, Fukuyama Taihei, Minami Yukiko, Shimizu Kazuya, Takai Yoshimi

Abstract excerpt

Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules that form homo- and hetero-trans-dimers (trans-interactions). Nectins first form cell-cell contact and then recruit cadherins to the nectin-based cell-cell contact sites to form adherens junctions cooperatively with cadherins. In addition, the trans-interactions of nectins induce the activation of Cdc42 and Rac small G proteins, which...

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Identifiers

PMID: 15485841
DOI: 10.1074/jbc.M408710200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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