Cellular Localization of Nectin-1 and Glycoprotein D during Herpes Simplex Virus Infection

doi:10.1128/jvi.77.16.8985-8999.2003

Article

Cellular Localization of Nectin-1 and Glycoprotein D during Herpes Simplex Virus Infection

28 Jul 2003

Abstract excerpt

During viral entry, herpes simplex virus (HSV) glycoprotein D (gD) interacts with a specific cellular receptor such as nectin-1 (PRR1/HveC/CD111) or the herpesvirus entry mediator A (HVEM/HveA). Nectin-1 is involved in cell-to-cell adhesion. It is located at adherens junctions, where it bridges cells through homophilic or heterophilic interactions with other nectins. Binding of HSV gD prevents nectin-1-mediated...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.