Article
Estrogen: consequences and implications of human mutations in synthesis and action.
The Journal of clinical endocrinology and metabolism - 1 Dec 1999
Grumbach M M, Auchus R J
Abstract excerpt
Recent developments have advanced our knowledge of the role of estrogen in the male. Studies of the mutations in CYP19, the gene encoding aromatase, in six females and two males and a mutant estrogen receptor alpha in a man are described. These observations provide illuminating new insights into the critical role of estrogen in the male (as well as female) in the pubertal growth spurt and skeletal maturation, and...
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