Genetic mutations resulting in estrogen insufficiency in the male.

Abstract excerpt

The biosynthesis of estrogens is catalyzed by an enzyme known as aromatase (aromatase cytochrome P450; P450 arom; the product of the CYP19 gene). In recent years a number of patients have been described suffering from aromatase deficiency due to mutations in the CYP19 gene, resulting in the synthesis of a non-functional gene product and a resulting failure to synthesize estrogens. Males with this condition have...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aromatase
• Share to Estrogens
• Share to Mice