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Article

Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4.

Journal of virology - 1 Nov 2004

Owen Andrew, Chandler Becky, Bray Patrick G, Ward Stephen A, Hart C Anthony, Back David J, Khoo Saye H

Abstract excerpt

The aim of this study was to investigate the relationship between lymphocyte P-glycoprotein (P-gp) expression and genotype in vivo and the expression of lymphocyte receptors critical in the life cycle of human immunodeficiency virus type 1 (HIV-1), i.e., CD4, CCR5, and CXCR4. Using flow cytometry to quantify each membrane receptor/transporter, we demonstrate a highly significant correlation between P-gp protein...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Protease Inhibitors

Share to Leukocytes, Mononuclear

Share to Microscopy, Confocal

Share to Receptors, CCR5

Share to Receptors, CXCR4

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 15479841
DOI: 10.1128/JVI.78.21.12022-12029.2004
PMCID: PMC523248

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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