Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Broad usage spectrum of G protein-coupled receptors as coreceptors by primary isolates of HIV.

AIDS (London, England) - 27 Apr 2009

Shimizu Nobuaki, Tanaka Atsushi, Oue Atsushi, Mori Takahisa, Ohtsuki Takahiro, Apichartpiyakul Chatchawann, Uchiumi Hideki, Nojima Yoshihisa, Hoshino Hiroo

Abstract excerpt

OBJECTIVE: HIV-1 can use various G protein-coupled receptors (GPCRs) in addition to CCR5 and CXCR4 as coreceptors; however, this type of HIV-1 infection has hardly been detected in vivo. The objective of this study was to elucidate the spectrum of GPCR usage by HIV-1 populations in vivo. DESIGN: CD4-expressing glioma cell line, NP-2/CD4, becomes highly susceptible to HIV-1 when the cells express GPCRs with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV-1
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to CD4-Positive T-Lymphocytes

Share to Cell Line, Tumor

Share to HIV Infections

Share to Receptors, G-Protein-Coupled

Share to Virus Replication

Source

Identifiers

PMID: 19307942
DOI: 10.1097/QAD.0b013e328326cc0d

Genes

CCR5
CXCR4
CCR1
CCR10
CCR3
CCR8
XCR1
CCR4
CCR6
CCR7
CXCR1
CXCR2
CXCR3
CXCR5
CXCR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Broad usage spectrum of G protein-coupled receptors as coreceptors by primary isolates of HIV.PMID 19307942Read ↗

Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency virusesSemantic proximity Read ↗

Use of GPR1, GPR15, and STRL33 as Coreceptors by Diverse Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Envelope ProteinsSemantic proximity Read ↗

A broad range of chemokine receptors are used by primary isolates of human immunodeficiency virus type 2 as coreceptors with CD4.Semantic proximity Read ↗

An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication of Human Immunodeficiency Virus Types 1 and 2 in Brain-Derived CellsSemantic proximity Read ↗

Patterns of chemokine receptor fusion cofactor utilization by human immunodeficiency virus type 1 variants from the lungs and blood.Semantic proximity Read ↗

Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease.Semantic proximity Read ↗

The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

Coreceptor usage by HIV-1 and HIV-2 primary isolates: The relevance of CCR8 chemokine receptor as an alternative coreceptorSemantic proximity Read ↗

Dual R3R5 tropism characterizes cerebrospinal fluid HIV-1 isolates from individuals with high cerebrospinal fluid viral load.Semantic proximity Read ↗

Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates, Like HIV-1 Isolates, Frequently Use CCR5 but Show Promiscuity in Coreceptor UsageSemantic proximity Read ↗

HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypes.Semantic proximity Read ↗

A short amino acid sequence containing tyrosine in the N-terminal region of G protein-coupled receptors is critical for their potential use as co-receptors for human and simian immunodeficiency viruses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.