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Article

COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code.

The Journal of cell biology - 11 Oct 2004

Wang Xiaodong, Matteson Jeanne, An Yu, Moyer Bryan, Yoo Jin-San, Bannykh Sergei, Wilson Ian A, Riordan John R, Balch William E

Abstract excerpt

Cystic fibrosis (CF) is a childhood hereditary disease in which the most common mutant form of the CF transmembrane conductance regulator (CFTR) DeltaF508 fails to exit the endoplasmic reticulum (ER). Export of wild-type CFTR from the ER requires the coat complex II (COPII) machinery, as it is sensitive to Sar1 mutants that disrupt normal coat assembly and disassembly. In contrast, COPII is not used to deliver...

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Identifiers

PMID: 15479737
DOI: 10.1083/jcb.200401035
PMCID: PMC2172508

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code.PMID 15479737Read ↗

Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic ReticulumSemantic proximity Read ↗

Non-conventional trafficking of the cystic fibrosis transmembrane conductance regulator through the early secretory pathway.Semantic proximity Read ↗

Identification of molecular determinants that modulate trafficking of DeltaF508 CFTR, the mutant ABC transporter associated with cystic fibrosis.Semantic proximity Read ↗

Removal of multiple arginine-framed trafficking signals overcomes misprocessing of delta F508 CFTR present in most patients with cystic fibrosis.Semantic proximity Read ↗

Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal.Semantic proximity Read ↗

The genetic basis of a craniofacial disease provides insight into COPII coat assembly.Semantic proximity Read ↗

Consequences of mutations in the genes of the ER export machinery COPII in vertebrates.Semantic proximity Read ↗

Interplay between ER exit code and domain conformation in CFTR misprocessing and rescue.Semantic proximity Read ↗

Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: not just from the endoplasmic reticulum to the Golgi.Semantic proximity Read ↗

ER export of ERGIC-53 is controlled by cooperation of targeting determinants in all three of its domains.Semantic proximity Read ↗

Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites.Semantic proximity Read ↗

CFTR folding and maturation in cells.Semantic proximity Read ↗

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