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Article

Chemical kinetic analysis of thermal decay of rhodopsin reveals unusual energetics of thermal isomerization and hydrolysis of Schiff base.

The Journal of biological chemistry - 4 Nov 2011

Liu Jian, Liu Monica Yun, Fu Li, Zhu Gefei Alex, Yan Elsa C Y

Abstract excerpt

The thermal properties of rhodopsin, which set the threshold of our vision, have long been investigated, but the chemical kinetics of the thermal decay of rhodopsin has not been revealed in detail. To understand thermal decay quantitatively, we propose a kinetic model consisting of two pathways: 1) thermal isomerization of 11-cis-retinal followed by hydrolysis of Schiff base (SB) and 2) hydrolysis of SB in dark...

Topics

Animals
Cattle
Evolution, Molecular
Eye Diseases
HEK293 Cells
Humans
Hydrogen Bonding
Hydrolysis
Kinetics
Models, Theoretical
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retinitis Pigmentosa

Rhodopsin

Schiff Bases

Temperature

Source

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Identifiers

PMID: 21921035
DOI: 10.1074/jbc.M111.280602
PMCID: PMC3207414

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