Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease.

Abstract excerpt

INTRODUCTION OR BACKGROUND: Charcot-Marie-Tooth (CMT) disease represents a broad group of inherited motor and sensory neuropathies which can originate from various genetic aberrations, e.g. mutations, deletions and duplications. SOURCES OF DATA: We performed a literature review on murine animal models of CMT disease with regard to experimental therapeutic approaches. Hereby, we focussed on the demyelinating...

Topics

• Animals
• Animals, Genetically Modified
• Charcot-Marie-Tooth Disease
• Disease Models, Animal
• Genetic Predisposition to Disease
• Mice
• Molecular Targeted Therapy
• Rats