Article
Heparin and activin-binding determinants in follistatin and FSTL3.
Endocrinology - 1 Jan 2005
Sidis Yisrael, Schneyer Alan L, Keutmann Henry T
Abstract excerpt
Local regulation of pituitary FSH secretion and many other cellular processes by follistatin (FS) can be ascribed to its potent ability to bind and bioneutralize activin, in conjunction with binding to cell surface heparan-sulfate proteoglycans through a basic heparin-binding sequence (HBS; residues 75-86) in the first of the three FS domains. The FS homolog, FSTL3, also binds activin, but lacks any HBS and...
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