Article
Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors.
Developmental biology - 1 Nov 2004
Hirsinger Estelle, Stellabotte Frank, Devoto Stephen H, Westerfield Monte
Abstract excerpt
In zebrafish, skeletal muscle precursors can adopt at least three distinct fates: fast, non-pioneer slow, or pioneer slow muscle fibers. Slow muscle fibers develop from adaxial cells and depend on Hedgehog signaling. We analyzed when precursors become committed to their fates and the step(s) along their differentiation pathway affected by Hedgehog. Unexpectedly, we find that embryos deficient in Hedgehog...
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