Article
HLA and hypocomplementemia: the disadvantage of carrying the HLA-B35 and the silent alleles of the C4 complement component.
International journal of immunopathology and pharmacology - 1 Jan 2000
Zorzetto M, Ricevuti G, Martinetti M, Gritti D, Gasparetto C, De Silvestri A, Salvaneschi L, Cuccia M
Abstract excerpt
Hypocomplementemia is an extremely complex phenomenon: we devoted our attention to its immunogenetic basis, particularly to the HLA haplotypes involved and to the study of C4 polymorphic genes. With this in mind we analyzed a group of unrelated patients with hypocomplementemia and 15 families suffering from specific C4 deficiency. Firstly, we performed a population analysis in order to identify a statistically...
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