Article
[Molecular analysis of structural abnormalities in papillary thyroid carcinoma gene].
Molekuliarnaia biologiia - 1 Jan 2000
Vasil'ev E V, Rumiantsev P O, Saenko V A, Il'in A A, Poliakova E Iu, Nemtsova M V, Zaletaev D V
Abstract excerpt
Rearrangements of the RET proto-oncogene (RET/PTC) and BRAF gene mutations are the major genetic alterations in the etiopathogenesis of papillary thyroid carcinoma (PTC). We have analyzed a series of 118 benign and malignant follicular cell-derived thyroid tumors for RET/PTC rearrangements and BRAF gene mutations. Oncogenic rearrangements of RET proto-oncogene was revealed by semiquantitative RT-PCR of...
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