Article
[Thyroid carcinoma: genetics, diagnosis, clinical features, and surgical treatment].
Nihon Geka Gakkai zasshi - 1 Jun 2002
Takami Hiroshi, Ikeda Yoshifumi, Tajima Gengo, Kan Shigenao, Kameyama Kaori
Abstract excerpt
The genes implicated in thyroid carcinoma can be categorized as oncogenes or tumor-suppressor genes. The RET oncogene has well-established roles in the development of both medullary and papillary thyroid carcinoma (PTC). Genetic testing for the germline RET mutation is commonly performed, and prophylactic thyroidectomy is carried out at an early stage. The demonstration of a RET rearrangement in a PTC patient may...
Topics
- Animals
- Carcinoma, Medullary
- Carcinoma, Papillary
- Drosophila Proteins
- Humans
- Mice
- Mice, Transgenic
- Mutation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-ret
- Receptor Protein-Tyrosine Kinases