Article
The NIQ of lopinavir is predictive of a 48-week virological response in highly treatment-experienced HIV-1-infected subjects treated with a lopinavir/ritonavir-containing regimen.
Antiviral therapy - 1 Aug 2004
Castagna Antonella, Gianotti Nicola, Galli Laura, Danise Anna, Hasson Hamid, Boeri Enzo, Hoetelmans Richard, Nauwelaers David, Lazzarin Adriano
Abstract excerpt
OBJECTIVE: To investigate the normalized inhibitory quotient (NIQ) of lopinavir (LPV) as a predictor of 48-week virological responses to a lopinavir/ritonavir (LPV/RTV)-containing regimen in highly treatment-experienced patients. DESIGN: We calculated the NIQ for 59 patients who completed 48 weeks' treatment and assessed the factors predicting a week-48 virological response. METHODS: The NIQ was calculated by...
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