Article
Predictive values of the human immunodeficiency virus phenotype and genotype and of amprenavir and lopinavir inhibitory quotients in heavily pretreated patients on a ritonavir-boosted dual-protease-inhibitor regimen.
Antimicrobial agents and chemotherapy - 1 May 2008
Barrail-Tran Aurélie, Morand-Joubert Laurence, Poizat Gwendoline, Raguin Gilles, Le Tiec Clotilde, Clavel François, Dam Elisabeth, Chêne Geneviève, Girard Pierre-Marie, Taburet Anne-Marie
Abstract excerpt
The inhibitory quotient (IQ) of human immunodeficiency virus (HIV) protease inhibitors (PIs), which is the ratio of drug concentration to viral susceptibility, is considered to be predictive of the virological response. We used several approaches to calculate the IQs of amprenavir and lopinavir i...
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