Isolation of suppressor genes that restore retrovirus susceptibility to a virus-resistant cell line.

Abstract excerpt

BACKGROUND: Genetic selections in mammalian cell lines have recently been developed for the isolation of mutant cells that are refractory to infection by retroviruses. These selections have been used to recover lines that block early postentry stages of infection, either before reverse transcription or before nuclear entry. The mechanisms of action of these blocks remain unknown. RESULTS: We have devised a method...

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