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Article

Disruption of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen leads to abortive episome persistence.

Journal of virology - 1 Oct 2004

Ye Feng-Chun, Zhou Fu-Chun, Yoo Seung Min, Xie Jian-Ping, Browning Philip J, Gao Shou-Jiang

Abstract excerpt

Latent nuclear antigen (LNA) is implicated in Kaposi's sarcoma-associated herpesvirus (KSHV) episome persistence. LNA colocalizes with KSHV episomes on chromosomes in metaphase, and it maintains the stability and replication of KSHV terminal repeat-containing plasmids. In this study, we examined the function of LNA in episome persistence in the context of full-length KSHV genome by mutagenesis analysis. We...

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Identifiers

PMID: 15452232
DOI: 10.1128/JVI.78.20.11121-11129.2004
PMCID: PMC521844

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Source receipt: pubmed, retrieved 7 Sept 2026.

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