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Article

Identification of the MMRN1 binding region within the C2 domain of human factor V.

The Journal of biological chemistry - 3 Dec 2004

Jeimy Samira B, Woram Rachael A, Fuller Nola, Quinn-Allen Mary Ann, Nicolaes Gerry A F, Dahlbäck Bjorn, Kane William H, Hayward Catherine P M

Abstract excerpt

In platelets, coagulation cofactor V is stored in complex with multimerin 1 in alpha-granules for activation-induced release during clot formation. The molecular nature of multimerin 1 factor V binding has not been determined, although multimerin 1 is known to interact with the factor V light chain. We investigated the region in factor V important for multimerin 1 binding using modified enzyme-linked immunoassays...

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Source

Identifiers

PMID: 15452129
DOI: 10.1074/jbc.M409866200

Genes

MMRN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Identification of the MMRN1 binding region within the C2 domain of human factor V.PMID 15452129Read ↗

Recent developments in the understanding of the combined deficiency of FV and FVIII.Semantic proximity Read ↗

Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity.Semantic proximity Read ↗

Structural characterization of carbohydrate binding by LMAN1 protein provides new insight into the endoplasmic reticulum export of factors V (FV) and VIII (FVIII).Semantic proximity Read ↗

A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function.Semantic proximity Read ↗

Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.Semantic proximity Read ↗

Conformational changes in the D' domain of von Willebrand factor induced by CYS 25 and CYS 95 mutations lead to factor VIII binding defect and multimeric impairment.Semantic proximity Read ↗

Genetic alteration of the D2 domain abolishes von Willebrand factor multimerization and trafficking into storage.Semantic proximity Read ↗

Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII.Semantic proximity Read ↗

Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII.Semantic proximity Read ↗

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Expression and characterization of recombinant human factor V and a mutant lacking a major portion of the connecting region.Semantic proximity Read ↗

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