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Article

Human neoplasms elicit multiple specific immune responses in the autologous host.

5 Dec 1995

Abstract excerpt

Expression of cDNA libraries from human melanoma, renal cancer, astrocytoma, and Hodgkin disease in Escherichia coli and screening for clones reactive with high-titer IgG antibodies in autologous patient serum lead to the discovery of at least four antigens with a restricted expression pattern in each tumor. Besides antigens known to elicit T-cell responses, such as MAGE-1 and tyrosinase, numerous additional...

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PMID: 8524854
DOI: 10.1073/pnas.92.25.11810

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