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Article

The La Autoantigen Is a Malignancy-Associated Cell Death Target That Is Induced by DNA-Damaging Drugs

15 Sept 2007

Abstract excerpt

PURPOSE: To evaluate the La autoantigen as a target for specific monoclonal antibody (mAb) binding in dead cancer cells after use of DNA-damaging chemotherapy. EXPERIMENTAL DESIGN: In vitro studies of La-specific 3B9 mAb binding to malignant and normal primary cells with and without cytotoxic drug treatment were done using immunoblotting and flow cytometry. Chromatin-binding studies and immunofluorescence...

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PMID: 17875783
DOI: 10.1158/1078-0432.ccr-07-0922

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