Article
Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood-onset mood disorders.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2005
Adams Jennifer H, Wigg Karen G, King Nicole, Burcescu Irina, Vetró Agnes, Kiss Eniko, Baji Ildikó, George Charles J, Kennedy James L, Kovacs Maria, Barr Cathy L
Abstract excerpt
Childhood-onset mood disorders (COMD) are often familial, and twin studies of COMD provide compelling evidence that genetic factors are involved. Deficits in neural plasticity have been suggested to underlie the development of depression. The receptor tropomyosin related kinase B (TrkB) and its ligand, brain derived neurotrophic factor (BDNF), play essential roles in neural plasticity, and mRNA expression of both...
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