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Article

The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge.

Infection and immunity - 1 Oct 2004

Kwon Hyog-Young, Ogunniyi A David, Choi Moo-Hyun, Pyo Suhk-Neung, Rhee Dong-Kwon, Paton James C

Abstract excerpt

Streptococcus pneumoniae usually colonizes the nasopharynx of humans asymptomatically but occasionally translocates from this niche to the lungs, the brain, and the blood, causing potentially fatal infections. Spread to other host tissues requires a significant morphological change and the expression of virulence factors, such as capsular polysaccharide, and virulence proteins, such as pneumolysin (Ply), PspA,...

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Identifiers

PMID: 15385462
DOI: 10.1128/IAI.72.10.5646-5653.2004
PMCID: PMC517602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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