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Article

Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.

Biochemistry - 28 Sept 2004

Clemente José C, Moose Rebecca E, Hemrajani Reena, Whitford Lisa R S, Govindasamy Lakshmanan, Reutzel Robbie, McKenna Robert, Agbandje-McKenna Mavis, Goodenow Maureen M, Dunn Ben M

Abstract excerpt

Protease inhibitor resistance still poses one of the greatest challenges in treating HIV. To better design inhibitors able to target resistant proteases, a deeper understanding is needed of the effects of accumulating mutations and the contributions of active- and nonactive-site mutations to the resistance. We have engineered a series of variants containing the nonactive-site mutations M46I and I54V and the...

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PMID: 15379553
DOI: 10.1021/bi049459m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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