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Article

Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors.

Retrovirology - 19 May 2020

Bastys Tomas, Gapsys Vytautas, Walter Hauke, Heger Eva, Doncheva Nadezhda T, Kaiser Rolf, de Groot Bert L, Kalinina Olga V

Abstract excerpt

BACKGROUND: HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response to therapy with protease inhibitors are found in the protease's active site that serves also as a binding pocket for the protease inhibitors, thus directly impacting the protease-inhibitor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32430025
DOI: 10.1186/s12977-020-00520-6
PMCID: PMC7236880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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