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Article

Mutations in apbC (mrp) prevent function of the alternative pyrimidine biosynthetic pathway in Salmonella typhimurium.

Journal of bacteriology - 1 Oct 1996

Petersen L, Downs D M

Abstract excerpt

The alternative pyrimidine biosynthetic (APB) pathway can synthesize the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine in Salmonella typhimurium independently of de novo purine biosynthesis. When mutants defective in function of the APB pathway were isolated, the predominan...

Topics

Alleles
Bacterial Proteins
Chromosome Mapping
Cloning, Molecular
Culture Media
Fructose
Mutagenesis, Insertional
Mutation
Phenotype
Pyrimidines
Ribonucleotides
Salmonella typhimurium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

Thiamine

Source

Open in PubMed Open full text

Identifiers

PMID: 8824612
DOI: 10.1128/jb.178.19.5676-5682.1996
PMCID: PMC178406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8824612-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutations in apbC (mrp) prevent function of the alternative pyrimidine biosynthetic pathway in Salmonella typhimurium.PMID 8824612Read ↗

The apbE gene encodes a lipoprotein involved in thiamine synthesis in Salmonella typhimurium.Semantic proximity Read ↗

A novel involvement of the PurG and PurI proteins in thiamine synthesis via the alternative pyrimidine biosynthetic (APB) pathway in Salmonella typhimurium.Semantic proximity Read ↗

Evidence for a new, oxygen-regulated biosynthetic pathway for the pyrimidine moiety of thiamine in Salmonella typhimurium.Semantic proximity Read ↗

Genetic analysis of metabolic crosstalk and its impact on thiamine synthesis in Salmonella typhimurium.Semantic proximity Read ↗

Synthesis of thiamine in Salmonella typhimurium independent of the purF function.Semantic proximity Read ↗

1-methylguanosine-deficient tRNA of Salmonella enterica serovar Typhimurium affects thiamine metabolism.Semantic proximity Read ↗

A mutant allele of rpoD results in increased conversion of aminoimidazole ribotide to hydroxymethyl pyrimidine in Salmonella enterica.Semantic proximity Read ↗

Evidence that rseC, a gene in the rpoE cluster, has a role in thiamine synthesis in Salmonella typhimurium.Semantic proximity Read ↗

The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains.Semantic proximity Read ↗

Altered pathway routing in a class of Salmonella enterica serovar Typhimurium mutants defective in aminoimidazole ribonucleotide synthetase.Semantic proximity Read ↗

Lesions in the nuo operon, encoding NADH dehydrogenase complex I, prevent PurF-independent thiamine synthesis and reduce flux through the oxidative pentose phosphate pathway in Salmonella enterica serovar typhimurium.Semantic proximity Read ↗

Plasticity in the purine-thiamine metabolic network of Salmonella.Semantic proximity Read ↗

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