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Article

Biological characterization of MLN944: a potent DNA binding agent.

Molecular cancer therapeutics - 1 Jan 2004

Sappal Darshan S, McClendon A Kathleen, Fleming James A, Thoroddsen Vala, Connolly Kelly, Reimer Corinne, Blackman Ronald K, Bulawa Christine E, Osheroff Neil, Charlton Peter, Rudolph-Owen Laura A

Abstract excerpt

MLN944 (XR5944) is a novel bis-phenazine that has demonstrated exceptional efficacy against a number of murine and human tumor models. The drug was reported originally as a dual topoisomerase I/II poison, but a precise mechanism of action for this compound remains to be determined. Several lines...

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PMID: 14749475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14749475-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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