Article
Is increased susceptibility to Balkan endemic nephropathy in carriers of common GSTA1 (*A/*B) polymorphism linked with the catalytic role of GSTA1 in ochratoxin a biotransformation? Serbian case control study and in silico analysis.
Toxins - 8 Aug 2014
Reljic Zorica, Zlatovic Mario, Savic-Radojevic Ana, Pekmezovic Tatjana, Djukanovic Ljubica, Matic Marija, Pljesa-Ercegovac Marija, Mimic-Oka Jasmina, Opsenica Dejan, Simic Tatjana
Abstract excerpt
Although recent data suggest aristolochic acid as a putative cause of Balkan endemic nephropathy (BEN), evidence also exists in favor of ochratoxin A (OTA) exposure as risk factor for the disease. The potential role of xenobiotic metabolizing enzymes, such as the glutathione transferases (GSTs), in OTA biotransformation is based on OTA glutathione adducts (OTHQ-SG and OTB-SG) in blood and urine of BEN patients....
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